Cabazitaxel

Cabazitaxel is a tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly. Among its listed roles, it functions as a antineoplastic agent and a microtubule-stabilising agent. Functionally, it is related to 10-deacetylbaccatin III. It is grouped under the following drug class(es): Antineoplastic agents, Cytotoxics, Microtubule inhibitors, Taxanes and Terpenes. Its therapeutic use is listed as anti-cancer agents and antineoplastics. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Jevtana, kabazitaxel and Cabazitaxelum. Its PubChem CID is 9854073.

CAS No 183133-96-2
Molecular Formula C45H57NO14
Molecular Weight 835.9 g/mol
Synonyms [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

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