Bedaquiline Fumarate is the fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used to treat pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5′-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. Its therapeutic use is listed as antibiotics and antituberculars. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Sirturo and 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol. Its PubChem CID is 24812732.
Bedaquiline fumarate
| CAS No | 845533-86-0 |
|---|---|
| Molecular Formula | C36H35BrN2O6 |
| Molecular Weight | 671.6 g/mol |
| Synonyms | (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol;(E)-but-2-enedioic acid |
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Frequently Asked Questions
Bedaquiline Fumarate is the fumarate salt form of bedaquiline, an orally bioavailable diarylquinoline antimycobacterial agent, that can be used to treat pulmonary multi-drug resistant tuberculosis (MDR-TB).
The listed CAS number is 845533-86-0.
The listed molecular formula is C36H35BrN2O6.
The listed molecular weight is 671.6 g/mol.
(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol;(E)-but-2-enedioic acid.
The source lists Sirturo and 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol.