Basifungin is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis. Its therapeutic use is listed as antifungals. The directory classifies it as a discontinued API with a semi-synthetic source/manufacturing origin. Other names for this substance include Aureobasidin A, Antibiotic R106I, NK-204 and basifunginum. Its PubChem CID is 9919816.
Basifungin
| CAS No | 127785-64-2 |
|---|---|
| Molecular Formula | C60H92N8O11 |
| Molecular Weight | 1101.4 g/mol |
| Synonyms | (3S,6S,9S,12R,15S,18S,21S,24S,27S)-3,6-dibenzyl-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone |
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Basifungin is an orally available cyclic depsipeptide antibiotic produced by Aureobasidium pullulans that is a fungicide at low concentrations. Aureobasidin A inhibits inositol phosphorylceramide synthase, an enzyme that catalyzes a key step in fungal sphingolipid biosynthesis.
The listed CAS number is 127785-64-2.
The listed molecular formula is C60H92N8O11.
The listed molecular weight is 1101.4 g/mol.
(3S,6S,9S,12R,15S,18S,21S,24S,27S)-3,6-dibenzyl-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone.
The source lists Aureobasidin A, Antibiotic R106I, NK-204 and basifunginum.