Avatrombopag Maleate is the maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity. Upon administration, avatrombopag binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily. Its therapeutic use is listed as hematologic agents. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include E5501 maleate and Doptelet (TN). Its PubChem CID is 9918581.
Avatrombopag maleate
| CAS No | 677007-74-8 |
|---|---|
| Molecular Formula | C33H38Cl2N6O7S2 |
| Molecular Weight | 765.7 g/mol |
| Synonyms | (Z)-but-2-enedioic acid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid |
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Avatrombopag Maleate is the maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity.
The listed CAS number is 677007-74-8.
The listed molecular formula is C33H38Cl2N6O7S2.
The listed molecular weight is 765.7 g/mol.
(Z)-but-2-enedioic acid;1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid.
The source lists E5501 maleate and Doptelet (TN).