Amodiaquine hydrochloride

Amodiaquine hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, that is toxic to the parasites. Its therapeutic use is listed as anti-infectives and antimalarials. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Camoquin Hcl and Amodiaquin dihydrochloride dihydrate. Its PubChem CID is 64646.