Amifostine Trihydrate (Ethyol) is a cytoprotective drug used in cancer therapy to shield healthy tissues from the damaging effects of chemotherapy (like cisplatin-induced kidney damage) and radiation, particularly preventing dry mouth (xerostomia) in head/neck cancer patients, by scavenging free radicals and binding to toxic metabolites, though its use is limited by side effects like low blood pressure. It’s given intravenously before treatment, acting selectively on healthy cells over tumor cells. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Ethyol (TN), Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester) and trihydrate. Its PubChem CID is 148139.
Amifostine trihydrate
| CAS No | 112901-68-5 |
|---|---|
| Molecular Formula | C5H21N2O6PS |
| Molecular Weight | 268.27 g/mol |
| Synonyms | 2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate |
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Amifostine Trihydrate (Ethyol) is a cytoprotective drug used in cancer therapy to shield healthy tissues from the damaging effects of chemotherapy (like cisplatin-induced kidney damage) and radiation, particularly preventing dry mouth (xerostomia) in head/neck cancer patients, by scavenging free radicals and binding to toxic metabolites, though its use is limited by side effects like low blood pressure.
The listed CAS number is 112901-68-5.
The listed molecular formula is C5H21N2O6PS.
The listed molecular weight is 268.27 g/mol.
2-(3-aminopropylamino)ethylsulfanylphosphonic acid;trihydrate.
The source lists Ethyol (TN), Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester) and trihydrate.