Aminocamptothecin is a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent’s antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. The directory classifies it as a discontinued API with a semi-synthetic source/manufacturing origin. Other names for this substance include 9-NH2-Camptothecin and 9-Amino-cpt. Its PubChem CID is 72402.
9-Aminocamptothecin
| CAS No | 91421-43-1 |
|---|---|
| Molecular Formula | C20H17N3O4 |
| Molecular Weight | 363.4 g/mol |
| Synonyms | (19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione |
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Frequently Asked Questions
Aminocamptothecin is a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages.
The listed CAS number is 91421-43-1.
The listed molecular formula is C20H17N3O4.
The listed molecular weight is 363.4 g/mol.
(19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione.
The source lists 9-NH2-Camptothecin and 9-Amino-cpt.