8-Chloroadenosine is an antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity. Upon administration, 8-chloro-adenosine is phosphorylated to form 8-chloro-adenosine triphosphate (8-chloro-ATP), which functions as a ribonucleoside analogue and competes with ATP during transcription. Therefore, this agent causes RNA synthesis inhibition, inhibits cellular proliferation, and induces apoptosis. The directory classifies it as a clinical API with a synthetic source/manufacturing origin. Other names for this substance include Adenosine, 8-chloro-, 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3 and 4-diol. It is also listed for alternate use as: API Intermediate. Its PubChem CID is 147569.
8-Chloroadenosine
| CAS No | 34408-14-5 |
|---|---|
| Molecular Formula | C10H12ClN5O4 |
| Molecular Weight | 301.69 g/mol |
| Synonyms | (2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
Zoho Contact Form
"*" indicates required fields
Frequently Asked Questions
8-Chloroadenosine is an antimetabolite and a chlorine derivative of the purine nucleoside adenosine, with potential antineoplastic activity.
The listed CAS number is 34408-14-5.
The listed molecular formula is C10H12ClN5O4.
The listed molecular weight is 301.69 g/mol.
(2R,3R,4S,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol.
The source lists Adenosine, 8-chloro-, 2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3 and 4-diol.