It is mainly used to prepare the subsequent key intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine, via chlorination. 6-Hydroxy-5-nitro-2-(propylthio)-4(3H)-pyrimidinone (also known as 5-nitro-2-(propylthio)pyrimidine-4,6-diol or its tautomer) is a critical early-stage intermediate in the industrial synthesis of the anti-platelet drug Ticagrelor.
6-Hydroxy-5-nitro-2-(propylthio)-4(3H)-pyrimidinone
| API Name | Ticagrelor |
|---|---|
| CAS No | 145783-13-7 |
| Molecular Formula | C7H9N3O4S |
| Molecular Weight | 231.23 g/mol |
| Synonyms | 4-hydroxy-5-nitro-2-propylsulfanyl-1H-pyrimidin-6-one |
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