6-Amino-1,3-diethyl-5-nitroso-2,4(1H,3H)-pyrimidinedione

The nitroso group at the 5-position serves as a reactive functional group that can undergo reduction or further transformation to form key amine or coupling intermediates. This enables subsequent condensation with substituted cinnamic acid derivatives and facilitates ring modification and chain attachment, ultimately contributing to the construction of the substituted pyrimidine framework required for the final drug molecule. 6-Amino-1,3-diethyl-5-nitroso-2,4(1H,3H)-pyrimidinedione is an important intermediate derived from 5,6-diamino-1,3-diethyluracil in the synthesis of Istradefylline.