It acts as a structural precursor that is reduced to an amine, subsequently cyclized, chlorinated, and coupled with 3-chloro-4-fluoroaniline to form the core 6,7-disubstituted quinazoline structure of the drug. 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester (and its methyl ester analog) serves as a key intermediate in the synthesis of Gefitinib, a tyrosine kinase inhibitor for cancer treatment.
5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester
| API Name | Gefitinib |
|---|---|
| CAS No | 1146162-38-0 |
| Molecular Formula | C10H11NO6 |
| Molecular Weight | 241.20 g/mol |
| Synonyms | ethyl 5-hydroxy-4-methoxy-2-nitrobenzoate |
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Frequently Asked Questions
It acts as a structural precursor that is reduced to an amine, subsequently cyclized, chlorinated, and coupled with 3-chloro-4-fluoroaniline to form the core 6,7-disubstituted quinazoline structure of the drug. 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester (and its methyl ester analog) serves as a key intermediate in the synthesis of Gefitinib, a tyrosine kinase inhibitor for cancer treatment.
The CAS number of 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester is 1146162-38-0.
The molecular formula of 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester is C10H11NO6.
The listed molecular weight of 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester is 241.20 g/mol.
5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester is listed as being used in connection with the following API: Gefitinib.
The listed synonym or IUPAC name for 5-Hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester is ethyl 5-hydroxy-4-methoxy-2-nitrobenzoate.