It serves as the core scaffold, mainly undergoing Palladium-catalyzed Suzuki-Miyaura coupling at the 5-position with (4-chlorophenyl)boronic acid to establish the 5-(4-chlorophenyl)-1H-pyrrolo[3-b]pyridine moiety essential for target binding. 5-bromo-1H-pyrrolo[3-b]pyridine (5-bromo-7-azaindole) is a critical key building block for the synthesis of the B-RAF inhibitor vemurafenib (PLX4032).
5-bromo-1H-pyrrolo[2,3-b]pyridine
| API Name | Vemurafenib |
|---|---|
| CAS No | 183208-35-7 |
| Molecular Formula | C7H5BrN2 |
| Molecular Weight | 197.03 g/mol |
| Synonyms | 5-bromo-1H-pyrrolo[2,3-b]pyridine |
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Frequently Asked Questions
It serves as the core scaffold, mainly undergoing Palladium-catalyzed Suzuki-Miyaura coupling at the 5-position with (4-chlorophenyl)boronic acid to establish the 5-(4-chlorophenyl)-1H-pyrrolo[3-b]pyridine moiety essential for target binding. 5-bromo-1H-pyrrolo[3-b]pyridine (5-bromo-7-azaindole) is a critical key building block for the synthesis of the B-RAF inhibitor vemurafenib (PLX4032).
The CAS number of 5-bromo-1H-pyrrolo[2,3-b]pyridine is 183208-35-7.
The molecular formula of 5-bromo-1H-pyrrolo[2,3-b]pyridine is C7H5BrN2.
The listed molecular weight of 5-bromo-1H-pyrrolo[2,3-b]pyridine is 197.03 g/mol.
5-bromo-1H-pyrrolo[2,3-b]pyridine is listed as being used in connection with the following API: Vemurafenib.
The listed synonym or IUPAC name for 5-bromo-1H-pyrrolo[2,3-b]pyridine is 5-bromo-1H-pyrrolo[2,3-b]pyridine.