5-Bromo-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran oxalate

It serves as a precursor to the cyanophthalan ring system, in which the 5-bromo group is substituted with a cyano group via metal-catalyzed cyanations, such as using CuCN or similar cyanating agents, followed by resolution to obtain the active (S)-enantiomer. 5-Bromo-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran, often used as its oxalate salt, is a key intermediate in the synthesis of the antidepressant Escitalopram (S-citalopram) and citalopram.

CAS No 64372-43-6
Molecular Formula C21H23BrFNO5
Molecular Weight 468.3 g/mol
Synonyms 3-[5-bromo-1-(4-fluorophenyl)-3H-2-benzofuran-1-yl]-N,N-dimethylpropan-1-amine;oxalic acid