It serves as a precursor to the cyanophthalan ring system, in which the 5-bromo group is substituted with a cyano group via metal-catalyzed cyanations, such as using CuCN or similar cyanating agents, followed by resolution to obtain the active (S)-enantiomer. 5-Bromo-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran, often used as its oxalate salt, is a key intermediate in the synthesis of the antidepressant Escitalopram (S-citalopram) and citalopram.
5-Bromo-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran oxalate
| CAS No | 64372-43-6 |
|---|---|
| Molecular Formula | C21H23BrFNO5 |
| Molecular Weight | 468.3 g/mol |
| Synonyms | 3-[5-bromo-1-(4-fluorophenyl)-3H-2-benzofuran-1-yl]-N,N-dimethylpropan-1-amine;oxalic acid |
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