5-Aza-2′-deoxycytidine (Decitabine, DAC) is an important epigenetic drug used mainly to treat hematologic malignancies like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) by inhibiting DNA methylation, which reactivates silenced tumor suppressor genes. Beyond cancer, its ability to alter gene expression makes it a significant research tool in understanding epigenetics and developing therapies for other diseases, including autoimmune disorders, by inducing demethylation and promoting cell differentiation. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Decitabina, 2-Desoxy-5-azacytidine and 5-Azadeoxycytidine. Its PubChem CID is 451668.
5-Aza-2′-deoxycytidine
| CAS No | 2353-33-5 |
|---|---|
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.21 g/mol |
| Synonyms | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one |
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5-Aza-2'-deoxycytidine (Decitabine, DAC) is an important epigenetic drug used mainly to treat hematologic malignancies like Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) by inhibiting DNA methylation, which reactivates silenced tumor suppressor genes.
The listed CAS number is 2353-33-5.
The listed molecular formula is C8H12N4O4.
The listed molecular weight is 228.21 g/mol.
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one.
The source lists Decitabina, 2-Desoxy-5-azacytidine and 5-Azadeoxycytidine.