It acts as the E-ring precursor for these topoisomerase I inhibitors. (4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano(3,4-f)indolizine-3,6,10(4H)-trione (CAS 110351-94-5) is a key chiral intermediate employed to synthesize camptothecin analogues, specifically anti-cancer drugs like Irinotecan (CPT-11), Topotecan, and Belotecan.
(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano(3,4-f)indolizine-3,6,10(4H)-trione
| API Name | Irinotecan |
|---|---|
| CAS No | 110351-94-5 |
| Molecular Formula | C13H13NO5 |
| Molecular Weight | 263.25 g/mol |
| Synonyms | (4S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10-trione |
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