It provides the required (3R, 4R)-stereochemistry for the piperidine moiety, which is subsequently reacted with 4-chloro-7H-pyrrolo[3-d]pyrimidine, followed by debenzylation and acetylation to produce Tofacitinib citrate. (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a critical chiral intermediate employed to synthesize the JAK inhibitor Tofacitinib (CP-690,550).
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
| API Name | Tofacitinib |
|---|---|
| CAS No | 477600-70-7 |
| Molecular Formula | C14H22N2 |
| Molecular Weight | 218.34 g/mol |
| Synonyms | (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine |
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Frequently Asked Questions
It provides the required (3R, 4R)-stereochemistry for the piperidine moiety, which is subsequently reacted with 4-chloro-7H-pyrrolo[3-d]pyrimidine, followed by debenzylation and acetylation to produce Tofacitinib citrate. (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is a critical chiral intermediate employed to synthesize the JAK inhibitor Tofacitinib (CP-690,550).
The CAS number of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is 477600-70-7.
The molecular formula of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is C14H22N2.
The listed molecular weight of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is 218.34 g/mol.
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is listed as being used in connection with the following API: Tofacitinib.
The listed synonym or IUPAC name for (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine is (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine.