3-Methyl-1-(2-piperidinophenyl)-1-butylamine, (S)

It reacts with 3-ethoxy-4-ethoxycarbonylphenylacetic acid via amide coupling to form the core structure of Repaglinide, typically involving catalysts like N,N′-dicyclohexylcarbodiimide (DCC) or N,N′-carbonyldiimidazole (CDI). (S)-3-Methyl-1-(2-piperidinophenyl)-1-butylamine is the crucial chiral amine intermediate employed to synthesize the antidiabetic drug Repaglinide.

API Name Repaglinide
CAS No 147769-93-5
Molecular Formula C16H26N2
Molecular Weight 246.39 g/mol
Synonyms (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine

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