3-iodo-1H-pyrazolo(3,4-d)pyrimidin-4-amine

It serves as a scaffolding agent, allowing for the Suzuki coupling of the 4-phenoxyphenyl group at the 3-position, followed by attachment of the piperidine ring at the 1-position and final acrylation to produce Ibrutinib. 3-Iodo-1H-pyrazolo[4-d]pyrimidin-4-amine is a key heterocyclic intermediate used to synthesize the BTK inhibitor Ibrutinib.

API Name Ibrutinib
CAS No 151266-23-8
Molecular Formula C5H4IN5
Molecular Weight 261.02 g/mol
Synonyms 3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine

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