The 3,5-hydroxyl groups are protected as benzoate esters, increasing lipophilicity and enabling controlled, stepwise chemical transformations in multistep synthesis.The compound has no direct pharmaceutical or biological application in its protected form. It is employed in medicinal chemistry and fine chemical synthesis, particularly for the preparation of fluorinated sugar analogs, nucleoside precursors, and enzyme-resistant carbohydrate derivatives. (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate is a fluorinated, stereochemically defined carbohydrate-derived lactone used exclusively as a synthetic intermediate.It consists of a five-carbon pentonic acid framework cyclized into a γ-lactone, bearing a fluoro and methyl substitution at C-2 that modulate chemical stability and reactivity.
(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate
| API Name | Sofosbuvir |
|---|---|
| CAS No | 874638-80-9 |
| Molecular Formula | C20H17FO6 |
| Molecular Weight | 372.3 g/mol |
| Synonyms | [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate |
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Frequently Asked Questions
The 3,5-hydroxyl groups are protected as benzoate esters, increasing lipophilicity and enabling controlled, stepwise chemical transformations in multistep synthesis.The compound has no direct pharmaceutical or biological application in its protected form. It is employed in medicinal chemistry and fine chemical synthesis, particularly for the preparation of fluorinated sugar analogs, nucleoside precursors, and enzyme-resistant carbohydrate derivatives. (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate is a fluorinated, stereochemically defined carbohydrate-derived lactone used exclusively as a synthetic intermediate.It consists of a five-carbon pentonic acid framework cyclized into a γ-lactone, bearing a fluoro and methyl substitution at C-2 that modulate chemical stability and reactivity.
The CAS number of (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate is 874638-80-9.
The molecular formula of (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate is C20H17FO6.
The listed molecular weight of (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate is 372.3 g/mol.
(2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate is listed as being used in connection with the following API: Sofosbuvir.
The listed synonym or IUPAC name for (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid gamma-lactone 3,5-dibenzoate is [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate.