2-Methoxyestradiol (2-ME2) is an estrogen metabolite with established use in cancer treatment and potential applications in cardiovascular health and inflammatory conditions. Its uses stem from its antiangiogenic (inhibiting blood vessel growth) and antimitotic (inhibiting cell division) properties, which target both tumor cells and their blood supply. By inducing apoptosis and cell cycle arrest, 2-ME2 inhibits tumor growth and metastasis, and it also has a role in preventing conditions like atherosclerosis. The directory classifies it as a discontinued API with a semi-synthetic source/manufacturing origin. Other names for this substance include Panzem, 2-methoxy-17beta-estradiol and 2-Hydroxyestradiol 2-methyl ether. Its PubChem CID is 66414.
2-Methoxyestradiol
| CAS No | 362-07-2 |
|---|---|
| Molecular Formula | C19H26O3 |
| Molecular Weight | 302.4 g/mol |
| Synonyms | (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
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Frequently Asked Questions
2-Methoxyestradiol (2-ME2) is an estrogen metabolite with established use in cancer treatment and potential applications in cardiovascular health and inflammatory conditions.
The listed CAS number is 362-07-2.
The listed molecular formula is C19H26O3.
The listed molecular weight is 302.4 g/mol.
(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol.
The source lists Panzem, 2-methoxy-17beta-estradiol and 2-Hydroxyestradiol 2-methyl ether.