2-Fluoro-4-nitrobenzoic acid

It is typically converted into 2-fluoro-4-aminobenzoic acid or its N-methyl amide derivative, which then serves as the amine component in a condensation reaction with 4-isothiocyano-2-trifluoromethylbenzonitrile to form the final thiohydantoin scaffold. 2-Fluoro-4-nitrobenzoic acid is a key fluorinated aromatic building block employed to synthesize Enzalutamide, a diarylhydantoin receptor inhibitor for prostate cancer.

API Name Enzalutamide
CAS No 403-24-7
Molecular Formula C7H4FNO4
Molecular Weight 185.11 g/mol
Synonyms 2-fluoro-4-nitrobenzoic acid

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