It also serves as a general protecting group for carboxylic acids in organic synthesis, creating esters, and as an intermediate for other compounds like the antifungal clotrimazole. 2-Chlorotrityl chloride (2-CTC) is used mainly as an acid-labile resin in Solid-Phase Peptide Synthesis (SPPS) to attach the first amino acid, allowing for mild cleavage to yield protected peptide fragments or fully deprotected peptides, crucial for synthesizing cyclic peptides and preventing side reactions like racemization and diketopiperazine formation.
2-Chlorotrityl chloride
| API Name | Clotrimazole |
|---|---|
| CAS No | 42074-68-0 |
| Molecular Formula | C19H14Cl2 |
| Molecular Weight | 313.2 g/mol |
| Synonyms | 1-chloro-2-[chloro(diphenyl)methyl]benzene |
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Frequently Asked Questions
It also serves as a general protecting group for carboxylic acids in organic synthesis, creating esters, and as an intermediate for other compounds like the antifungal clotrimazole. 2-Chlorotrityl chloride (2-CTC) is used mainly as an acid-labile resin in Solid-Phase Peptide Synthesis (SPPS) to attach the first amino acid, allowing for mild cleavage to yield protected peptide fragments or fully deprotected peptides, crucial for synthesizing cyclic peptides and preventing side reactions like racemization and diketopiperazine formation.
The CAS number of 2-Chlorotrityl chloride is 42074-68-0.
The molecular formula of 2-Chlorotrityl chloride is C19H14Cl2.
The listed molecular weight of 2-Chlorotrityl chloride is 313.2 g/mol.
2-Chlorotrityl chloride is listed as being used in connection with the following API: Clotrimazole.
The listed synonym or IUPAC name for 2-Chlorotrityl chloride is 1-chloro-2-[chloro(diphenyl)methyl]benzene.