2-Chlorotrityl chloride

It also serves as a general protecting group for carboxylic acids in organic synthesis, creating esters, and as an intermediate for other compounds like the antifungal clotrimazole. 2-Chlorotrityl chloride (2-CTC) is used mainly as an acid-labile resin in Solid-Phase Peptide Synthesis (SPPS) to attach the first amino acid, allowing for mild cleavage to yield protected peptide fragments or fully deprotected peptides, crucial for synthesizing cyclic peptides and preventing side reactions like racemization and diketopiperazine formation.