It is further converted into the 6-bromo derivative or substituted directly at the 2-position for final drug formulation. 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[3-d]pyrimidin-7-one (CAS 1013916-37-4) is a crucial intermediate in the synthesis of Palbociclib (a CDK4/6 inhibitor), typically produced by the cyclization of 1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethanone with ethyl acetate.
2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one
| API Name | Palbociclib |
|---|---|
| CAS No | 1013916-37-4 |
| Molecular Formula | C13H14ClN3O |
| Molecular Weight | 263.72 g/mol |
| Synonyms | 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one |
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It is further converted into the 6-bromo derivative or substituted directly at the 2-position for final drug formulation. 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido[3-d]pyrimidin-7-one (CAS 1013916-37-4) is a crucial intermediate in the synthesis of Palbociclib (a CDK4/6 inhibitor), typically produced by the cyclization of 1-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)ethanone with ethyl acetate.
The CAS number of 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is 1013916-37-4.
The molecular formula of 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is C13H14ClN3O.
The listed molecular weight of 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is 263.72 g/mol.
2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is listed as being used in connection with the following API: Palbociclib.
The listed synonym or IUPAC name for 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido(2,3-d)pyrimidin-7-one is 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one.