2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

It serves as a penultimate precursor that reacts with 1-(2-hydroxyethyl)piperazine to introduce the piperazine side chain, completing the molecule. 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide is a key intermediate in the synthesis of Dasatinib, a tyrosine kinase inhibitor.

API Name Dasatinib
CAS No 302964-08-5
Molecular Formula C16H13Cl2N5OS
Molecular Weight 394.3 g/mol
Synonyms N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide