(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropane-carboxylic acid

It provides the core cyclopropane structure, serving as the carboxylic acid precursor that is coupled with 5-fluoropyridin-2-amine to form the final active ingredient. (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropanecarboxylic acid is a key chiral intermediate employed to synthesize Lemborexant (E2006/Dayvigo).

API Name Lemborexant
CAS No 1369769-35-6
Molecular Formula C17H17FN2O3
Molecular Weight 316.33 g/mol
Synonyms cis-(1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)cyclopropane-1-carboxylic acid

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