The methanesulfonate (mesylate) group acts as a good leaving group, allowing nucleophilic substitution with the appropriate piperazine-containing side chain. This reaction forms the key C–O linkage, helping construct the final antifungal drug molecule, Itraconazole. 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel- is an important activated intermediate in the synthesis of Itraconazole.
1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel
| API Name | Itraconazole |
|---|---|
| CAS No | 67914-86-7 |
| Molecular Formula | C14H15Cl2N3O5S |
| Molecular Weight | 408.3 g/mol |
| Synonyms | [(2R,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate |
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Frequently Asked Questions
The methanesulfonate (mesylate) group acts as a good leaving group, allowing nucleophilic substitution with the appropriate piperazine-containing side chain. This reaction forms the key C–O linkage, helping construct the final antifungal drug molecule, Itraconazole. 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel- is an important activated intermediate in the synthesis of Itraconazole.
The CAS number of 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel is 67914-86-7.
The molecular formula of 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel is C14H15Cl2N3O5S.
The listed molecular weight of 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel is 408.3 g/mol.
1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel is listed as being used in connection with the following API: Itraconazole.
The listed synonym or IUPAC name for 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate, (2R,4R)-rel is [(2R,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate.