1-Methylindole

It is mainly used to construct the 3-(2-chloropyrimidin-4-yl)-1-methylindole intermediate, which constitutes a key part of the final drug molecule. 1-Methylindole is a critical raw material and structural building block in the synthesis of Osimertinib (Tagrisso), a third-generation EGFR tyrosine kinase inhibitor.

API Name Osimertinib
CAS No 603-76-9
Molecular Formula C9H9N
Molecular Weight 131.17 g/mol
Synonyms 1-methylindole