1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose

This intermediate contains the essential C-aryl-glucoside linkage, which is the defining structural feature of Dapagliflozin. By providing the correct stereochemistry and pre-assembled aryl–glucose framework, it enables efficient downstream transformations to obtain the final API. Its use helps ensure high purity, structural accuracy, and process efficiency in the production of Dapagliflozin, making it a critical building block in the drug’s industrial synthesis. 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-deoxy-β-D-glucopyranose is an advanced chiral intermediate used in the manufacturing of Dapagliflozin, an SGLT2 inhibitor for the treatment of type-2 diabetes.

API Name Dapagliflozin
CAS No 960404-86-8
Molecular Formula C21H25ClO7
Molecular Weight 424.9 g/mol
Synonyms (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol