This intermediate contains the essential C-aryl-glucoside linkage, which is the defining structural feature of Dapagliflozin. By providing the correct stereochemistry and pre-assembled aryl–glucose framework, it enables efficient downstream transformations to obtain the final API. Its use helps ensure high purity, structural accuracy, and process efficiency in the production of Dapagliflozin, making it a critical building block in the drug’s industrial synthesis. 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-deoxy-β-D-glucopyranose is an advanced chiral intermediate used in the manufacturing of Dapagliflozin, an SGLT2 inhibitor for the treatment of type-2 diabetes.
1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose
| API Name | Dapagliflozin |
|---|---|
| CAS No | 960404-86-8 |
| Molecular Formula | C21H25ClO7 |
| Molecular Weight | 424.9 g/mol |
| Synonyms | (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol |
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Frequently Asked Questions
This intermediate contains the essential C-aryl-glucoside linkage, which is the defining structural feature of Dapagliflozin. By providing the correct stereochemistry and pre-assembled aryl–glucose framework, it enables efficient downstream transformations to obtain the final API. Its use helps ensure high purity, structural accuracy, and process efficiency in the production of Dapagliflozin, making it a critical building block in the drug’s industrial synthesis. 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-deoxy-β-D-glucopyranose is an advanced chiral intermediate used in the manufacturing of Dapagliflozin, an SGLT2 inhibitor for the treatment of type-2 diabetes.
The CAS number of 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose is 960404-86-8.
The molecular formula of 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose is C21H25ClO7.
The listed molecular weight of 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose is 424.9 g/mol.
1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose is listed as being used in connection with the following API: Dapagliflozin.
The listed synonym or IUPAC name for 1-C-(4-Chloro-3-((4-ethoxyphenyl)methyl)phenyl)-I+–D-glucopyranose is (2S,3R,4S,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-2,3,4,5-tetrol.