1-(2-Pyrimidyl)piperazine hydrochloride

In the manufacturing route, it provides the pyrimidyl-substituted piperazine nucleus that is essential for buspirone’s anxiolytic activity. The hydrochloride salt improves handling and reactivity, and this intermediate undergoes further alkylation and coupling steps to attach the butyl chain and imide moiety, ultimately yielding buspirone with the required structural features for serotonin (5-HT₁A) receptor modulation. 1-(2-Pyrimidyl)piperazine hydrochloride serves as a key intermediate in the synthesis of buspirone.