In the manufacturing route, it provides the pyrimidyl-substituted piperazine nucleus that is essential for buspirone’s anxiolytic activity. The hydrochloride salt improves handling and reactivity, and this intermediate undergoes further alkylation and coupling steps to attach the butyl chain and imide moiety, ultimately yielding buspirone with the required structural features for serotonin (5-HT₁A) receptor modulation. 1-(2-Pyrimidyl)piperazine hydrochloride serves as a key intermediate in the synthesis of buspirone.
1-(2-Pyrimidyl)piperazine hydrochloride
| CAS No | 94021-22-4 |
|---|---|
| Molecular Formula | C8H13ClN4 |
| Molecular Weight | 200.67 g/mol |
| Synonyms | 2-piperazin-1-ylpyrimidine;hydrochloride |
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Frequently Asked Questions
In the manufacturing route, it provides the pyrimidyl-substituted piperazine nucleus that is essential for buspirone’s anxiolytic activity. The hydrochloride salt improves handling and reactivity, and this intermediate undergoes further alkylation and coupling steps to attach the butyl chain and imide moiety, ultimately yielding buspirone with the required structural features for serotonin (5-HT₁A) receptor modulation. 1-(2-Pyrimidyl)piperazine hydrochloride serves as a key intermediate in the synthesis of buspirone.
The CAS number of 1-(2-Pyrimidyl)piperazine hydrochloride is 94021-22-4.
The molecular formula of 1-(2-Pyrimidyl)piperazine hydrochloride is C8H13ClN4.
The listed molecular weight of 1-(2-Pyrimidyl)piperazine hydrochloride is 200.67 g/mol.
The listed synonym or IUPAC name for 1-(2-Pyrimidyl)piperazine hydrochloride is 2-piperazin-1-ylpyrimidine;hydrochloride.