1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile

This compound provides the essential pyrazolo[4-b]pyridine backbone with the 2-fluorobenzyl substituent, a key feature of Riociguat’s structure, according to patents and chemical synthesis descriptions. 1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile (FPPCN) is a crucial intermediate or building block in synthesizing Riociguat (Adempas), a drug for pulmonary hypertension, where it forms the core structure that gets further modified to attach the pyrimidine ring and carbamate group, ultimately creating the active sGC stimulator.