(-)-Salinosporamide A

Salinosporamide A is a salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers. Among its listed roles, it functions as a antineoplastic agent and a proteasome inhibitor. It is a salinosporamide, an organochlorine compound, an organic heterobicyclic compound, a beta-lactone and a gamma-lactam. It is grouped under the following drug class(es): Proteasome inhibitors. The directory classifies it as a discontinued API with a fermentation-derived source/manufacturing origin. Other names for this substance include Marizomib, Homosalinosporamide A, NPI-0052 and marizomibum. Its PubChem CID is 11347535.