Gold Sodium Thiomalate is the sodium salt of gold thiomalic acid, an organogold compound with antirheumatic and potential antineoplastic activities. Gold sodium thiomalate (GST) appears to inhibit the activity of atypical protein kinase C iota (PKCiota) by forming a cysteinyl-aurothiomalate adduct with the cysteine residue Cys-69 within the PB1 binding domain of PKCiota. This prevents the binding of Par6 (Partitioning defective protein 6) to PKCiota, thereby inhibiting PKCiota-mediated oncogenic signaling, which may result in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. Its therapeutic use is listed as anti-inflammatories and antirheumatic agents. The directory classifies it as a commercial API with a mineral/inorganic source/manufacturing origin. Other names for this substance include Tauredon, Chrysothios and Myocrisin. Its PubChem CID is 22318.
Gold sodium thiomalate
| CAS No | 12244-57-4 |
|---|---|
| Molecular Formula | C4H3AuNa2O4S |
| Molecular Weight | 390.08 g/mol |
| Synonyms | disodium;gold(1+);2-sulfidobutanedioate |
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Frequently Asked Questions
Gold Sodium Thiomalate is the sodium salt of gold thiomalic acid, an organogold compound with antirheumatic and potential antineoplastic activities.
The listed CAS number is 12244-57-4.
The listed molecular formula is C4H3AuNa2O4S.
The listed molecular weight is 390.08 g/mol.
disodium;gold(1+);2-sulfidobutanedioate.
The source lists Tauredon, Chrysothios and Myocrisin.