Estramustine is a synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. It is grouped under the following drug class(es): Alkylating agents, Estrogens and Microtubule inhibitors. Its therapeutic use is listed as antineoplastics. The directory classifies it as a commercial API with a semi-synthetic source/manufacturing origin. Other names for this substance include Estramustinum and Estramustina. It is also listed for alternate use as: API Intermediate. Its PubChem CID is 259331.
Estramustine
| CAS No | 2998-57-4 |
|---|---|
| Molecular Formula | C23H31Cl2NO3 |
| Molecular Weight | 440.4 g/mol |
| Synonyms | [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate |
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Estramustine is a synthetic molecule combining estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion.
The listed CAS number is 2998-57-4.
The listed molecular formula is C23H31Cl2NO3.
The listed molecular weight is 440.4 g/mol.
[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate.
The source lists Estramustinum and Estramustina.