Esketamine hydrochloride

Esketamine Hydrochloride is the hydrochloride salt form of esketamine, that is the S(+) enantiomer of ketamine. It is mainly used as a nasal spray under the brand name Spravato for the treatment of treatment-resistant depression (TRD) and major depressive disorder with suicidal ideation or behavior in adults. Esketamine functions as a dissociative hallucinogen and functions mainly as an NMDA receptor antagonist, which helps increase glutamate release and improve synaptic functioning in the brain, contributing to its antidepressant effects. Its therapeutic use is listed as central nervous system (CNS) agents and psychedelics. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Ketanest S, (S)-(+)-ketamine hydrochloride, Spravato and Esketamine HCl. It is listed as a controlled drug substance (Schedule III). Its PubChem CID is 44632368.