Eflornithine hydrochloride

Eflornithine Hydrochloride is the hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. It is grouped under the following drug class(es): Trypanosomiasis agents. Its therapeutic use is listed as anti-infectives. The directory classifies it as a commercial API with a synthetic source/manufacturing origin. Other names for this substance include Eflornithine hydrochloride monohydrate and Iwilfin. Its PubChem CID is 441361.