Dotatate is a specialized somatostatin analog used mainly to diagnose and treat neuroendocrine tumors (NETs). It works by binding to somatostatin receptors, which are often overexpressed on these cancer cells, making them highly visible on imaging or directly delivering radiation to the tumor. The directory classifies it as a commercial API with a peptide source/manufacturing origin. Other names for this substance include DOTA-octreotate, DOTA-TATE and Oxodotreotide. It is also listed for alternate use as: API Intermediate. Its PubChem CID is 11170867.
Dotatate
| CAS No | 177943-88-3 |
|---|---|
| Molecular Formula | C65H90N14O19S2 |
| Molecular Weight | 1435.6 g/mol |
| Synonyms | (2S,3R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[(2R)-3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]propanoyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic acid |
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Frequently Asked Questions
Dotatate is a specialized somatostatin analog used mainly to diagnose and treat neuroendocrine tumors (NETs). It works by binding to somatostatin receptors, which are often overexpressed on these cancer cells, making them highly visible on imaging or directly delivering radiation to the tumor.
The listed CAS number is 177943-88-3.
The listed molecular formula is C65H90N14O19S2.
The listed molecular weight is 1435.6 g/mol.
(2S,3R)-2-[[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[(2R)-3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]propanoyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic acid.
The source lists DOTA-octreotate, DOTA-TATE and Oxodotreotide.