Camptothecin

Camptothecin is a pyranoindolizinoquinoline that is pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline that is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer). Among its listed roles, it functions as a EC 5.99.1.2 (DNA topoisomerase) inhibitor, an antineoplastic agent, a genotoxin and a plant metabolite. It is a pyranoindolizinoquinoline, a tertiary alcohol, a delta-lactone and a quinoline alkaloid. It is grouped under the following drug class(es): Topoisomerase inhibitors. The directory classifies it as a commercial API with a natural source/manufacturing origin. Other names for this substance include Camptothecine, (S)-(+)-Camptothecin and d-Camptothecin. Its PubChem CID is 24360.

CAS No 7689-03-4
Molecular Formula C20H16N2O4
Molecular Weight 348.4 g/mol
Synonyms (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

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