Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include Benzo(1, 2-b:4, 3-b’)dipyrrol-4-ol, 6, 6′-(carbonylbis(imino-1H-indole-5, 2-diylcarbonyl))bis(8-(chloromethyl)-3, 6, 7, 8-tetrahydro-1-methyl-, (S-(R* and R*))). Its PubChem CID is 60794.
Bizelesina
| CAS No | 129655-21-6 |
|---|---|
| Molecular Formula | C43H36Cl2N8O5 |
| Molecular Weight | 815.7 g/mol |
| Synonyms | 1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea |
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Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis.
The listed CAS number is 129655-21-6.
The listed molecular formula is C43H36Cl2N8O5.
The listed molecular weight is 815.7 g/mol.
1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea.
The source lists Benzo(1, 2-b:4, 3-b')dipyrrol-4-ol, 6, 6'-(carbonylbis(imino-1H-indole-5, 2-diylcarbonyl))bis(8-(chloromethyl)-3, 6, 7, 8-tetrahydro-1-methyl-, (S-(R* and R*))).