Atorvastatin sodium

Atorvastatin Sodium is the sodium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins including small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation. It is grouped under the following drug class(es): Cholesterol-reducing agents and Statins. Its therapeutic use is listed as cardiovascular. The directory classifies it as a clinical API with a synthetic source/manufacturing origin. Other names for this substance include Sodium atorvastate, Atorvastatin monosodium salt, (3R and 5R)-Atorvastatin Sodium Salt. Its PubChem CID is 23665101.