Amikacin Sulfate is the sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically in contact with 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. It is grouped under the following drug class(es): Aminoglycosides. Its therapeutic use is listed as antibiotics and antituberculars. The directory classifies it as a commercial API with a peptide source/manufacturing origin. Other names for this substance include Pierami, Amikin, Arikayce and Amiglyde. Its PubChem CID is 38351.
Amikacin sulfate
| CAS No | 39831-55-5 |
|---|---|
| Molecular Formula | C22H47N5O21S2 |
| Molecular Weight | 781.8 g/mol |
| Synonyms | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid |
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Frequently Asked Questions
Amikacin Sulfate is the sulfate salt of amikacin, a broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property.
The listed CAS number is 39831-55-5.
The listed molecular formula is C22H47N5O21S2.
The listed molecular weight is 781.8 g/mol.
(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid.
The source lists Pierami, Amikin, Arikayce and Amiglyde.