Achromobacter glutaminase (Asparaginase)

Achromobacter glutaminase (L-asparaginase) is used mainly in the treatment of acute lymphoblastic leukemia (ALL). It works by depleting L-asparagine, an amino acid essential for leukemic cells. This inhibits protein synthesis, leading to cancer cell death. It is especially useful in patients allergic or resistant to E. coli–derived asparaginase. It is grouped under the following drug class(es): Cytotoxics. The directory classifies it as a commercial API with a peptide source/manufacturing origin. Other names for this substance include NSC-279192, L-ASNase/L-GLNase and Glutaminase-asparaginase. Its PubChem SID is 142605.