6-Aminonicotinamide

6-aminonicotinamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, including cisplatin, in killing cancer cells. Among its listed roles, it functions as a teratogenic agent, an antimetabolite and an EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor. It is an aminopyridine, a primary amino compound and a monocarboxylic acid amide. Functionally, it is related to 6-aminonicotinic acid. The directory classifies it as a discontinued API with a synthetic source/manufacturing origin. Other names for this substance include 2-Amino-5-carbamoylpyridine and 6-amino-3-pyridinecarboxamide. It is also listed for alternate use as: API Intermediate. Its PubChem CID is 9500.