4-Isothiocyanato-2-(trifluoromethyl)benzonitrile

It reacts with N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide to form the thiohydantoin ring (thioimidazolinone) of Enzalutamide. This compound is typically prepared from 4-amino-2-(trifluoromethyl)benzonitrile using thiophosgene. 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile is a crucial intermediate in the synthesis of Enzalutamide.

API Name Enzalutamide
CAS No 143782-23-4
Molecular Formula C9H3F3N2S
Molecular Weight 228.20 g/mol
Synonyms 4-isothiocyanato-2-(trifluoromethyl)benzonitrile

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