Phenyl hydrogen ((R)-1-(6-amino-9H-purin-9-YL)propan-2-yloxy)methylphosphonate

It is also identified as a monophenol ester impurity related to the production of these drugs. Phenyl hydrogen ((R)-1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methylphosphonate is a critical intermediate employed to synthesize HIV-1 reverse transcriptase inhibitors, mainly Tenofovir Alafenamide and Tenofovir Disoproxil.

CAS No 379270-35-6
Molecular Formula C15H18N5O4P
Molecular Weight 363.31 g/mol
Synonyms [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphinic acid

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