(tert-Butyl) 2-ethyl (2R,5S)-5-aminopiperidine-1,2-dicarboxylate

It provides the enantiomerically pure 5‑amino‑piperidine scaffold, which is then transformed through protection, functionalization (e.g., conversion to the benzyloxyamino derivative), and cyclization steps to construct the diazabicyclooctane (DABCO) core of Avibactam. This intermediate is essential for ensuring the correct stereochemistry and efficient assembly of the active drug molecule. (tert‑Butyl) 2‑ethyl (2R,5S)‑5‑aminopiperidine‑1,2‑dicarboxylate is a chiral intermediate employed to synthesize the β‑lactamase inhibitor Avibactam.