It provides the substituted pyrimidine core linked with an acrylamide side chain, which is essential for building the final xanthine-like structure. The compound undergoes further cyclization, functional group modification, and substitution reactions to construct the fused heterocyclic system and introduce pharmacologically important substituents required for Istradefylline’s activity as an adenosine A₂A receptor antagonist. (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide acts as a key intermediate in the synthesis of Istradefylline.
(E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide
| API Name | Istradefylline |
|---|---|
| CAS No | 187393-68-6 |
| Molecular Formula | C19H24N4O5 |
| Molecular Weight | 388.4 g/mol |
| Synonyms | (E)-N-(4-amino-1,3-diethyl-2,6-dioxopyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)prop-2-enamide |
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Frequently Asked Questions
It provides the substituted pyrimidine core linked with an acrylamide side chain, which is essential for building the final xanthine-like structure. The compound undergoes further cyclization, functional group modification, and substitution reactions to construct the fused heterocyclic system and introduce pharmacologically important substituents required for Istradefylline’s activity as an adenosine A₂A receptor antagonist. (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide acts as a key intermediate in the synthesis of Istradefylline.
The CAS number of (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide is 187393-68-6.
The molecular formula of (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide is C19H24N4O5.
The listed molecular weight of (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide is 388.4 g/mol.
(E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide is listed as being used in connection with the following API: Istradefylline.
The listed synonym or IUPAC name for (E)-N-(6-Amino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)acrylamide is (E)-N-(4-amino-1,3-diethyl-2,6-dioxopyrimidin-5-yl)-3-(3,4-dimethoxyphenyl)prop-2-enamide.