It is often produced by deprotecting the Boc-protected amine, followed by N-acylation with n-octanoic acid or n-octanoyl chloride, and final salt formation, providing the (1R, 2R)-stereochemistry crucial for therapeutic activity. (1R,2R)-2-Amino-1-(2,3-dihydrobenzo[b]dioxin-6-yl)-3-(pyrrolidin-1-yl)propan-1-ol is a key penultimate intermediate in the synthesis of Eliglustat Tartrate, a drug approved for treating Gaucher’s disease.
2-Amino-1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-3-(pyrrolidin-1-yl)propan-1-ol, (1R,2R)
| API Name | Eliglustat tartrate |
|---|---|
| CAS No | 491833-28-4 |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.35 g/mol |
| Synonyms | (1R,2R)-2-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-pyrrolidin-1-ylpropan-1-ol |
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