(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Although doripenem is a related carbapenem API, publicly available sources tie this specific intermediate to meropenem processes, and there is no strong evidence that Applications include an established doripenem synthetic route. (4‑Nitrophenyl)methyl (4R,5R,6S)‑3‑[(diphenoxyphosphoryl)oxy]‑6‑[(1R)‑1‑hydroxyethyl]‑4‑methyl‑7‑oxo‑1‑azabicyclo[3.2.0]hept‑2‑ene‑2‑carboxylate is a chemical intermediate in the synthesis of carbapenem antibiotics, most notably meropenem, where it functions as an activated bicyclic β‑lactam ester that is condensed with a protected side‑chain precursor in early steps of the API synthesis.

CAS No 90776-59-3
Molecular Formula C29H27N2O10P
Molecular Weight 594.5 g/mol
Synonyms (4-nitrophenyl)methyl (4R,5R,6S)-3-diphenoxyphosphoryloxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate