It is produced through the chiral reduction of 3-chloropropiophenone using reagents like Eap2BCl. (1R)-3-chloro-1-phenylpropan-1-ol acts as a crucial chiral building block in the synthesis of (S)-dapoxetine, typically via an SN2 displacement with 1-naphthol, causing an inversion of configuration to (S)-3-(naphthalen-1-yloxy)-1-phenylpropan-1-ol.
(1R)-3-chloro-1-phenylpropan-1-ol
| API Name | Dapoxetine |
|---|---|
| CAS No | 100306-33-0 |
| Molecular Formula | C9H11ClO |
| Molecular Weight | 170.63 g/mol |
| Synonyms | (1R)-3-chloro-1-phenylpropan-1-ol |
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