L-Valine benzyl ester hydrochloride

It reacts via N-alkylation with 4-bromomethyl-2′-cyanobiphenyl, followed by N-acylation with valeryl chloride, tetrazole ring formation, and debenzylation to produce the antihypertensive drug. L-Valine benzyl ester hydrochloride is a crucial chiral intermediate employed to synthesize Valsartan to introduce the (S)-valine moiety.

API Name Valsartan
CAS No 2462-34-2
Molecular Formula C12H18ClNO2
Molecular Weight 243.73 g/mol
Synonyms benzyl (2S)-2-amino-3-methylbutanoate;hydrochloride

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